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POST-DOCTORAL FELLOW
NIH/NCI-funded post-doctoral fellowship opportunity to study mechanisms of metastasis of ovarian cancer in vitro and in vivo. Projects involve elucidating the relative contributions of cell-cell adhesion, cell-matrix adhesion, and proteolysis in ovarian cancer intraperitoneal dissemination and range in scope from proteinase biochemistry, evaluation of adhesion-signaling pathways, organotypic cultures and murine tumor models. Experience with mammalian cell culture required; experience with cell imaging and/or murine tumor models is a major plus. The research will take place in the Dept. of Pathology and Anatomical Sciences, Univ. of Missouri, Columbia, MO and the anticipated start date for the position is April 2007. Please send CV, a brief (1-2 paragraph) statement of research interests/experience, and a list of at least 3 references to stackm@health.missouri.edu.
Laboratory website: www.stackscientific.com (note that the lab recently moved and the website contains the old contact information)
Recent Stack Lab Publications
Munshi, H.G. and Stack, M.S. (2006)Reciprocal Interactions Between Adhesion Receptor Signaling and MMP Regulation, for Cancer Metastasis Reviews 25: 45-56.
Ghosh, S., Johnson J.J., Sen, R., Mukhopadhyay S., Liu, Y., Zhang, F., Wei, Y., Chapman, H.A., and Stack, M.S. (2006) Functional Relevance of Urinary-type Plasminogen Activator Receptor (uPAR)-alpha3beta1 Integrin Association in Proteinase Regulatory Pathways. J. Biol. Chem.281:13021-9.
Ravosa, M.J., Kunwar, R., Stock, S.R. & Stack, M.S. (2007) Pushing the limit: Masticatory stress and adaptive plasticity in mammalian craniomandibular joints. J. Exp. Biol. 210: 628-641 (commentary in “Inside JEB”).
Barbolina, M.V., Ariztia, E.V., Adley, B.P., Liu, Y., and Stack, M.S. (2007)Epigenetic Regulation of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) Activity in Ovarian Carcinoma Cells via Collagen-Induced Egr-1 Expression. J. Biol. Chem., in press.
Symowicz, J.E., Adley, B.P., Gleason, K., Johnson, J.J., Ghosh, S., Fishman, D.A., Hudson, L.G. and Stack, M.S. (2007) Engagement of Collagen-Binding Integrins Promotes MMP-9-Dependent E-Cadherin Ectodomain Shedding in Ovarian Carcinoma Cells. Cance Research, in press.
Information on Columbia, MO
Columbia is a small (approximately 100,000 people) college town in mid-Missouri. The cost of living and housing is low and there are ample opportunities for outdoor activities such as hiking, biking, and water sports. For more information on Columbia, please see http://www.gocolumbiamo.com/
Contact:
M. Sharon Stack
stackm@health.missouri.edu
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