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Below are our current protease-related job listings:


M.Sc., Ph.D., and PDF positions
University of Sherbrooke (Québec), Canada

Seeking highly motivated graduate students and PDFs to investigate the interplay of caspases and cancer

The Denault’s laboratory is seeking MSc, PhD, and PDF candidates with interest in the interplay of caspases and cancer, more specifically, how caspase-mediated proteolysis influences growth factor signaling in colorectal cancer (CRC). The position is available immediately at the Institut de Pharmacologie de Sherbrooke (IPS; yes another IPS!) of the University of Sherbrooke (Québec), Canada. MSc and PhD trainees will enroll into the graduate program in pharmacology.

The available projects will require working with cell cultures, tissues from patients, several techniques of molecular biology (siRNA, CRISPR, lentivirus), cell biology (confocal and STED microscopy, subcellular fractionation), biochemistry (enzymology, protein-protein interaction analysis) as well as proteomics.

The lab is part of the Department of Pharmacology and Physiology at the IPS, in Sherbrooke, Province of Québec, Canada. Sherbrooke is a university town nestled in the beautiful Eastern Townships of the Province, surrounded by mountains, rivers, and lakes.

Candidates will benefit from the complementary expertise of researchers at the Department as well as their close collaborators from other departments and institutions. Our Institute has state of the art facilities including STED and light sheet microscopy, NMR for protein structure, -omics, small animal imaging, and more, and is situated on the same campus as a medical school hospital and a clinical research center. Aside from lab work and the few courses, trainees will have the opportunity to learn French; attend training classes in scientific writing, IP, career building, teaching, and more; make new friends; and enjoy the Canadian outdoors.


We are looking for an enthusiastic, hard-working, motivated, rigorous, and interactive person with keen interest in proteolysis, cancer biology, and intracellular trafficking, and the following qualifications:

• Undergraduate degree for MSc candidates, MSc/equivalent for PhD, or PhD for PDF, in a relevant discipline (cell biology, biochemistry, molecular biology, biotechnology, etc.)
• Excellent academic track record;
• Publications in peer-reviewed journals for candidates with a PhD degree;
• Some lab experience in cellular and molecular biology techniques.

How to apply: By email at jean-bernard.denault@USherbrooke.ca; send a short motivation letter, CV, contacts for two referees, and latest (non-official) transcripts for M.Sc./Ph.D. candidates.

posted 2019-03-11


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